Smoking influences the association between apolipoprotein E and lipids: The national heart, lung, and blood institute family heart study |
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Authors: | Luc Djoussé Richard H Myers Hilary Coon Donna K Arnett Michael A Province R Curtis Ellison |
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Affiliation: | (1) Section of Preventive Medicine & Epidemiology, Evans Department of Medicine, Boston University School of Medicine, Room B-612, 715 Albany St., 02118 Boston, Massachusetts;(2) Department of Psychiatry, University of Utah, Salt Lake City, Utah;(3) Division of Epidemiology, University of Minnesota, Minneapolis, Minnesota;(4) Division of Biostatistics, Washington University, St Louis, Missouri |
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Abstract: | Apolipoprotein E allele 4 (apo ɛ4) and smoking each have been associated with an unfavorable lipid profile. We used data collected on 1,472 subjects in the
National Heart, Lung, and Blood Institute Family Heart Study to assess whether smoking interacts with apo ɛ4 to influence the levels of plasma lipids. We dichotomized smoking and apo ɛ4 and used analysis of covariance to estimate the means of lipids. Smokers had lower body mass index, were younger, and consumed
less fruits and vegetables. Among individuals without apo ɛ4, comparing nonsmokers with smokers, mean low density lipoprotein cholesterol (LDL) was 129.3 and 134.4 mg/dL, respectively,
for women and 126.1 and 127.6 mg/dL, respectively, for men. Among subjects with an apo ɛ4 allele, corresponding means were 132.0, and 152.9 mg/dL, respectively, for women and 131.3 and 137.3 mg/dL, respectively,
for men (P for interaction <0.001 for women and 0.11 for men). A similar interaction was observed for total cholesterol among women
(P=0.02). This study shows a statistically significant effect modification of the relation of apo ɛ4 to LDL and total cholesterol by smoking among women. Smoking may enhance genetic susceptibility to an unfavorable lipid profile
among subjects with apo ɛ4. |
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