A derivation of the particle size weighting factor in the measurement of rate coefficients

An analysis of the weighted concentration curve shows that the proper weighting for disperse populations of particle sizes varies according to the method of analysis used in data regression. A general form for the weighting factor is derived for the integral method. Several forms of the weighting factor for diffusion with a surface resistance are shown and the effect of particle size variations is demonstrated for a sample of Sepharose 6B (Pharmacia).