心肌搏动细胞传感器及其在药物分析中的应用

针对产品全生命周期管理的特点，将元数据建模技术与本体相结合建立基于元数据的产品数据本体,提出基于元数据的产品概念模型和面向产品全生命周期的产品数据模型；通过分析元数据建模的元层次，提出了基于元数据的产品数据本体建模体系结构以及通用描述，并给出了某汽轮机产品数据模型实例.实例表明,在产品全生命周期管理中采用基于元数据的产品数据本体，能够有效地保证数据的安全性和一致性，可方便地进行模型集成和信息共享，满足实际产品设计和生产过程中出现的所有可能的情况.

Beating cardiac cell-based biosensor and its application in drugs screening

A novel cell-based biosensor using light-addressable potentiometric sensor(LAPS) for beating detection of cells was developed to real-time and noninvasively monitor the physiological parameters cultured cardiac cells.When cardiac cells were cultured on the surface of LAPS,changes of extracellular potentials and cell shapes with their mechanically beatings modulated the photocurrents in the LAPS system and changed the output of the sensor.Typical cardiac stimulant(isoproterenol) and relaxant(carbamylcholine) were taken as example to detect biosensor's potential application in drugs' active compounds screening.Experiment showed that the drugs had characteristic effects on the cardiac cells in term of changes of beating frequency,amplitude and duration.