Cocoa polyphenols are absorbed in Caco-2 cell model of intestinal epithelium |
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Authors: | Kosińska Agnieszka Andlauer Wilfried |
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Affiliation: | University of Applied Sciences Valais, Institute of Life Technologies, Route du Rawyl 47, CH-1950 Sion, Switzerland; Division of Food Science, Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, Tuwima 10, 10-747 Olsztyn, Poland. |
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Abstract: | Cocoa is an abundant source of polyphenols, mainly flavan-3-ol monomers and polymers. In the literature, there are contradictory data on the absorption limit of procyanidins in humans. In our study, the Caco-2 cell model of intestinal epithelium was used to determine the absorption and secretion of cocoa flavan-3-ols. Three compounds: (+)-catechin, (-)-epicatechin and procyanidin B2 were detected and quantified at the receiver side of Caco-2 monolayer after 2h transport experiment. The obtained results of apparent permeability coefficient suggest paracellular route of transport of investigated compounds. Additionally, the results suggest that compounds of cocoa powder purified extract are able to affect tight junction functioning. |
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Keywords: | Cocoa powder Caco-2 cells Epithelial transport Procyanidins Paracellular absorption |
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