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RADIOIMMUNOTOXICOLOGICAL EFFECT OF ENRICHED URANIUM ON CENTRAL AND PERIPHERAL IMMUNE CELLS AND THE PROTECTIVE ACTION OF IL-1 AND IL-2
引用本文:朱寿彭,赖冠华,王六一.RADIOIMMUNOTOXICOLOGICAL EFFECT OF ENRICHED URANIUM ON CENTRAL AND PERIPHERAL IMMUNE CELLS AND THE PROTECTIVE ACTION OF IL-1 AND IL-2[J].核技术(英文版),1994(2).
作者姓名:朱寿彭  赖冠华  王六一
作者单位:Faculty of Radiological Medicine,Suzhou Medical College,Suzhou 215007,China
摘    要:RADIOIMMUNOTOXICOLOGICALEFFECTOFENRICHEDURANIUMONCENTRALANDPERIPHERALIMMUNECELLSANDTHEPROTECTIVEACTIONOFIL-1ANDIL-2¥ZhuShoupe...


RADIOIMMUNOTOXICOLOGICAL EFFECT OF ENRICHED URANIUM ON CENTRAL AND PERIPHERAL IMMUNE CELLS AND THE PROTECTIVE ACTION OF IL-1 AND IL-2
Zhu Shoupeng, Lai Guanhua and Wang Liuyi.RADIOIMMUNOTOXICOLOGICAL EFFECT OF ENRICHED URANIUM ON CENTRAL AND PERIPHERAL IMMUNE CELLS AND THE PROTECTIVE ACTION OF IL-1 AND IL-2[J].Nuclear Science and Techniques,1994(2).
Authors:Zhu Shoupeng  Lai Guanhua and Wang Liuyi
Abstract:Accumulation of enriched 235U-UO2F2 in the body had injurious effects on theimmune function of central and peripheral immune cells. After an intravenousinjection of beaU--UO,F,, the spontaneous 'H--TdR incorporation in thymocytes andbone marrow cells decreased, with the thymocytes damaged more markedly. Theproliferation ability of spleen T and B lymphocytes were both inhibited, with Blymphocytes inhibited more severely. In spleen B lymphocytes the IL-- 1 production andIL--2 consumption were diminished. The inhibition of spleen B lymphocyteproliferation by "U-- UOZFZ was partially restored by adding exogenous IL-- 1 or IL--2to the cultured lymphocytes obtained from "U injected mice.
Keywords:Enriched uranium  Radioimmunotoxicological effect  Interleukin-1  Interleukin-2  Immune cells  Protective action
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