Development of drug adsorbates onto soluble inorganic silicate glass surface: example with acetaminophen |
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Authors: | Yoanna Hristova Peter Djambaski Biserka Samuneva Nadya Rangelova Svetla Bogdanova |
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Affiliation: | (1) Department of Silicate Technology, University of Chemical Technology and Metallurgy, 8 Kliment Ohridski Blvd., Sofia, 1756, Bulgaria;(2) Faculty of Pharmacy, Medical University, Sofia, 2, Dunav St., Sofia, 1000, Bulgaria |
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Abstract: | A ternary melt-derived inorganic glass system (Igl) of composition corresponding to 62SiO2, 35Na2O, 3Al2O3 (wt.%) has been formulated and studied as a drug carrier. The [Al2O3/Na2O] ratio is less than one and the aluminium ion is a network former that retards the glass dissolution. The processing conditions lead to a brittle, easily grinding, amorphous product. The Igl structure was proven by IR-spectroscopy, energy-dispersive spectrometry, X-ray diffraction, scanning electron microscopy. A very important fact established is that the Igl corrosion (dissolution) is pH-dependent. Inorganic glass system was transformed into model acetaminophen (APH) adsorbate (APH/Igla 1:1(w/w)) with mild experimental conditions and evaluated as a drug carrier. No interactions between Igl and APH during the processing were proven. Besides, APH settles onto the glass surface as crystalline phase. A lower extent of corrosion, apparent solubility and delayed in vitro APH release from the adsorbate in water and artificial gastric juice in comparison to the samples untreated drug and APH/Iglm physical mixture were established. It is hypothesized that the glass decomposition products, formed into contact with a solvent, initiate interactions with APH at the glass/solution interface. Similar behaviour of the Igl and its drug adsorbates could be expected in gastro-intestinal tract. |
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