| 姜黄素烟酸酯的合成 |
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| 引用本文： | 何黎琴,王效山,罗丹.姜黄素烟酸酯的合成[J].化学世界,2011,52(3):175-177. |
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| 作者姓名： | 何黎琴 王效山 罗丹 |
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| 作者单位： | 安徽中医学院药学院,安徽省现代中药重点实验室,安徽,合肥,230031 |
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| 摘 要： | 以烟酸和姜黄素为原料,采用酰氯法经过二步反应合成了姜黄素烟酸酯,经红外光谱、核磁共振氢谱及质谱确证了该目标化合物的化学结构.考察了原料配比、反应温度、反应液PH值三个因素对反应产率的影响,优选出最佳合成工艺.最佳合成工艺为:n(姜黄素):n(烟酰氯盐酸盐)=1:4(摩尔比)、反应温度25～30℃、反应液PH值为7～8....
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| 关 键 词： | 姜黄素 烟酸 姜黄素烟酸酯 合成 |
Synthesis of Curcumin Nicotinate |
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| HE Li-qin,WANG Xiao-shan,LUO Dan.Synthesis of Curcumin Nicotinate[J].Chemical World,2011,52(3):175-177. |
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| Authors: | HE Li-qin WANG Xiao-shan LUO Dan |
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| Affiliation: | HE Li-qin,WANG Xiao-shan,LUO Dan(Anhui Traditional Chinese Medicine College,Anhui Key Laboratory of Modernized Chinese Material Medical,Anhui Hefei 230031,China) |
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| Abstract: | Curcumin dinicotinate was synthesized from nicotinic acid and curcumin by employing the acylchloride method.Its chemical structure was confirmed by MS,IR,and ～1H NMR spectroscopy.The results showed that the optimal synthetic conditions were as follows: curcumin∶nicotinyl chloride=1∶4(n∶n),reaction temperature 25～30 ℃ and pH=7～8.The yield of curcumin dinicotinate was 62 %. |
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| Keywords: | curcumin nicotinic acid curcumin dinicotinate synthesis |
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