| 海洋放线菌发酵产物的乙酰胆碱酯酶抑制活性研究 |
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| 引用本文： | 史大华,吴少杰,刘玮炜,许瑞波,张鑫鑫,唐烨,吴娴,陈晓敏. 海洋放线菌发酵产物的乙酰胆碱酯酶抑制活性研究[J]. 淮海工学院学报, 2011, 0(3): 82-84 |
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| 作者姓名： | 史大华 吴少杰 刘玮炜 许瑞波 张鑫鑫 唐烨 吴娴 陈晓敏 |
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| 作者单位： | [1]淮海工学院化学工程学院 ,江苏连云港222005 [2]淮海工学院江苏省海洋生物技术重点建设实验室,江苏连云港222005 [3]淮海工学院海洋学院,江苏连云港222005 |
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| 基金项目： | 江苏省自然科学基金资助项目（BK2009640）; 江苏省海洋生物技术重点建设实验室开放课题（2010HS04）; 淮海工学院引进人才启动项目（KQ08015,KQ09029） |
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| 摘 要： | 利用海洋高氏一号培养基对36株海洋放线菌进行培养。发酵处理4 d天后发酵液用乙酸乙酯进行提取。用Ellman法检测发酵产物的乙酰胆碱酯酶抑制活性。21株海洋放线菌的发酵产物对乙酰胆碱酯酶具有显著的抑制活性,其中,放线菌LYG22对乙酰胆碱酯酶的抑制活性最好,对AChE的抑制率达到48.58%。
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| 关 键 词： | 海洋放线菌 乙酰胆碱酯酶 抑制活性 |
Study on the Acetylcholinesterase Inhibition Activities by Extracts of Marine Actinomycetes |
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| SHI Da-huaa,b,WU Shao-jiec,LIU Wei-weia,XU Rui-boa,ZHANG Xin-xina,TANG Yea,WU Xiana,CHEN Xiao-min. Study on the Acetylcholinesterase Inhibition Activities by Extracts of Marine Actinomycetes[J]. Journal of Huaihai Institute of Technology:Natural Sciences Edition, 2011, 0(3): 82-84 |
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| Authors: | SHI Da-huaa b WU Shao-jiec LIU Wei-weia XU Rui-boa ZHANG Xin-xina TANG Yea WU Xiana CHEN Xiao-min |
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| Affiliation: | a(a.School of Chemical Engineering;b.Jiangsu Key Laboratory of Marine Biotechnology;c.School of Marine Science,Huaihai Institute of Technology,Lianyungang 222005,China) |
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| Abstract: | 36 marine actinomycetes were cultured with Gauze＇s medium No.1.The fermentation broth was extracted with ethyl acetate.The acetylcholinesterase inhibition activities of the extracts were tested using Ellman＇s method.21 extracts of the marine actinomycetes showed significant acetylcholinesterase inhibition activities.Among them,the extract of marine actinomycete LYG22 had the best acetylcholinesterase inhibition activity with the inhibition rate of 48.58%. |
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| Keywords: | marine actinomycetes acetylcholinesterase inhibition activity |
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