Aqueous urea as a model system for bi-exponential relaxation |
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| Authors: | R. Adam Horch Mark D. Does |
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| Affiliation: | (1) Department of Biomedical Engineering, Vanderbilt University School of Engineering, Nashville, USA;(2) Department of Radiology and Radiological Sciences, Vanderbilt University School of Medicine, Nashville, USA;(3) Vanderbilt University Institute of Imaging Science, AA 1105 Medical Center North 1161 21st Avenue South, Nashville, TN 37232-2310, USA |
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| Abstract: | Object To evaluate the utility of aqueous urea, doped inner- and outer-sphere relaxation agents, as an adjustable two-component model system. Materials and Methods T2 was measured from 12 molal urea mixtures at pH 7.0 with varying amounts of the MnCl2 and FeO1.44 (Feridex®, Berlex Inc, Montville, NJ). Results Bi-exponential relaxation was observed, with rates that were bilinearly related to [MnCl2] and [FeO1.44]. FeO1.44 had comparable relaxivities on both urea and water, while MnCl2 relaxivity was > 15x larger for water than for urea. Conclusion Aqueous urea, doped with inner- and outer-sphere contrast agents, is a two-compartment model system, which can be exhibit a wide range of different T2s and signal fractions. |
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| Keywords: | NMR Relaxometry T2 Multi-exponential Urea |
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