| 一种合成喹啉-3-羧酸甲酯的新方法 |
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| 引用本文： | 梅苏宁,俞迪虎,李勇. 一种合成喹啉-3-羧酸甲酯的新方法[J]. 精细化工中间体, 2009, 39(2): 41-43 |
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| 作者姓名： | 梅苏宁 俞迪虎 李勇 |
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| 作者单位： | 浙江大学,材料与化学工程学院,浙江,杭州,310027;浙江大学,材料与化学工程学院,浙江,杭州,310027;浙江大学,材料与化学工程学院,浙江,杭州,310027 |
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| 摘 要： | 以喹啉-2,3-二羧酸为原料,经过脱羧、酰氯化和醇解等3步反应来合成喹啉-3-羧酸甲酯,总收率达83．5％。用红外光谱及核磁共振图谱对目标产物进行了结构表征,产物的熔点为74～75℃。讨论并证实了第一步脱羧反应的反应机理。
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| 关 键 词： | 喹啉-2 3-二羧酸 喹啉-3-羧酸甲酯 脱羧 酰氯化 醇解 |
A New Method of Synthesis of 3-Quinolinecarboxylic Acid Methyl Ester |
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| MEI Su-ning,YU Di-hu,LI Yong. A New Method of Synthesis of 3-Quinolinecarboxylic Acid Methyl Ester[J]. Fine Chemical Intermediates, 2009, 39(2): 41-43 |
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| Authors: | MEI Su-ning YU Di-hu LI Yong |
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| Affiliation: | College of Material Science and Chemical Engineering;Zhejiang University;Hangzhou 310027;China |
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| Abstract: | 3-Quinolinecarboxylic acid methyl ester was synthesized from quinoline-2,3-dicarboxylic acid in steps of decarboxylation,chlorization and alcoholysis in an overall yield of 83.5%.The structure of the target compound was identified by IR and 1H NMR.Its melting point was 74～75℃.The mechanism of decarboxylation was discussed. |
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| Keywords: | quinol ine-2 3-dicarboxylic acid 3-quinolinecarboxylic acid methyl ester decarboxylation chlorination alcoholysis |
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