| 1-硫杂-4,8-二氮杂螺[4.5]癸烷-3-羧酸类衍生物的合成 |
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| 引用本文： | 李莹,李阳,顾为,王鑫,聂爱华.1-硫杂-4,8-二氮杂螺[4.5]癸烷-3-羧酸类衍生物的合成[J].陕西化工,2014(3):404-407. |
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| 作者姓名： | 李莹 李阳 顾为 王鑫 聂爱华 |
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| 作者单位： | [1]广西医科大学研究生院,广西南宁530021 [2]军事医学科学院毒物药物研究所,北京100850 [3]齐齐哈尔医学院药学院,黑龙江齐齐哈尔161006 |
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| 基金项目： | 国家自然科学基金资助项目（30878136）;北京市自然科学基金资助项目（7122131） |
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| 摘 要： | 以L-半胱氨酸为起始原料,经酯化、成环、水解、缩合、去保护五步反应合成了6个新型的1-硫杂4,8-二氮杂螺4.5]癸烷-3-羧酸类衍生物,其结构用1H NMR和LC-MS表征.
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| 关 键 词： | 螺环 缩合 衍生物 合成 |
Synthesis of 4,8-diaza-1-thia-spiro [4.5] decane-3-carboxylic acid derivatives |
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| LI YingGraduate School,Guangxi Medical University,Nanning,China ;Institute of Pharmcology and Toxicology,Academy of Military Medical Sciences,Beijing,China LI YangInstitute of Pharmcology and Toxicology,Academy of Military Medical Sciences,Beijing,China GU WeiInstitute of Pharmcology and Toxicology,Academy of Military Medical Sciences,Beijing,China WANG XinInstitute of Pharmcology and Toxicology,Academy of Military Medical Sciences,Beijing,China;College of Pharmacy,Qiqihar Medical University,Qiqihaer,China NIE Ai-hua.Synthesis of 4,8-diaza-1-thia-spiro [4.5] decane-3-carboxylic acid derivatives[J].Applied Chemical Industry,2014(3):404-407. |
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| Authors: | LI YingGraduate School Guangxi Medical University Nanning China ;Institute of Pharmcology and Toxicology Academy of Military Medical Sciences Beijing China LI YangInstitute of Pharmcology and Toxicology Academy of Military Medical Sciences Beijing China GU WeiInstitute of Pharmcology and Toxicology Academy of Military Medical Sciences Beijing China WANG XinInstitute of Pharmcology and Toxicology Academy of Military Medical Sciences Beijing China;College of Pharmacy Qiqihar Medical University Qiqihaer China NIE Ai-hua |
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| Affiliation: | LI Ying(Graduate School, Guangxi Medical University, Nanning 530021, China ;Institute of Pharmcology and Toxicology,Academy of Military Medical Sciences, Beijing 100850, China) LI Yang(Institute of Pharmcology and Toxicology,Academy of Military Medical Sciences, Beijing 100850, China) GU Wei(Institute of Pharmcology and Toxicology,Academy of Military Medical Sciences, Beijing 100850, China) WANG Xin(Institute of Pharmcology and Toxicology,Academy of Military Medical Sciences, Beijing 100850, China;College of Pharmacy, Qiqihar Medical University,Qiqihaer 161006, China) NIE Ai-hua(Institute of Pharmcology and Toxicology,Academy of Military Medical Sciences, Beijing 100850, China) |
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| Abstract: | With L（＋）-cysteine as raw material,synthetic strategy was completed by esterification,cyclization,hydrolysis,condensation and deprotection,six novel 4,8-diaza-1-thia-spiro 4.5] decane-3-carboxylic acid derivatives were synthesized,the structures were characterized by 1H NMR and LC-MS. |
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| Keywords: | spiro condensation derivatives synthesis |
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