| 2-硝基咪唑的合成工艺改进 |
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| 引用本文： | 李晖,弓巧娟,王卫兵,姚陈忠,韩秋萍.2-硝基咪唑的合成工艺改进[J].陕西化工,2014(3):425-426. |
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| 作者姓名： | 李晖 弓巧娟 王卫兵 姚陈忠 韩秋萍 |
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| 作者单位： | 运城学院应用化学系,山西运城044000 |
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| 基金项目： | 国家自然科学基金青年科学基金项目（51101138）;运城学院院级项目（2008114） |
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| 摘 要： | 氨基乙醛缩二甲醇与S-甲基异硫脲硫酸盐或O-甲基异脲硫酸盐缩合后,再加硫酸催化环合,得到2-氨基咪唑硫酸盐,经重氮化、硝化反应,得到目标化合物2-硝基咪唑,总收率49.9％.
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| 关 键 词： | 2-硝基咪唑 2-氨基咪唑 合成 |
Improvement on the synthesis of 2-nitroimidazole |
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| LI Hui.Improvement on the synthesis of 2-nitroimidazole[J].Applied Chemical Industry,2014(3):425-426. |
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| Authors: | LI Hui |
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| Affiliation: | LI Hui(Department of Applied Chemistry, Yuncheng University, Yuncheng 044000, China) GONG Qiao-juan(Department of Applied Chemistry, Yuncheng University, Yuncheng 044000, China) WANG Wei-bing(Department of Applied Chemistry, Yuncheng University, Yuncheng 044000, China) YAO Chen-zhong(Department of Applied Chemistry, Yuncheng University, Yuncheng 044000, China) HAN Qiu-ping(Department of Applied Chemistry, Yuncheng University, Yuncheng 044000, China) |
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| Abstract: | An improved method for the synthesis of 2-nitroimidazole was reported.2-Aminoimidazole was first prepared by one-pot reaction of aminoacetaldehyde dimethyl acetal and S-methylisothiourea sulphate or O-methylisourea sulphate.Then,2-nitroimidazole was obtained via diazotization followed by nitration of2-aminoimidazole.The overall yield of the route was 49.9％. |
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| Keywords: | 2-nitroimidazole 2-aminoimidazole synthesis |
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