| 一种2,3,5,6-四甲基吡嗪的简便合成方法研究 |
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| 引用本文： | 赵伟,刘春波,王昆淼,韩敬美,何沛,刘志华. 一种2,3,5,6-四甲基吡嗪的简便合成方法研究[J]. 香料香精化妆品, 2013, 0(5): 17-18 |
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| 作者姓名： | 赵伟 刘春波 王昆淼 韩敬美 何沛 刘志华 |
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| 作者单位： | 云南烟草科学研究院／云南省烟草化学重点实验室,云南昆明650106 |
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| 基金项目： | 中国烟草总公司科技重大专项项目（110201001001）;云南中烟工业公司科技开发计划（2012JC02） |
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| 摘 要： | 利用磷酸氢二铵促进梅拉德反应的性质,通过其与3-羟基-2-丁酮反应合成2,3,5,6-四甲基吡嗪,同时比较考察了3-羟基-2-丁酮与不同铵盐的反应。结果表明,3-羟基-2-丁酮与磷酸氢二铵在室温条件下静置24 h,过滤洗涤即得到2,3,5,6-四甲基吡嗪,产率可达到50%以上,且操作简便,适于工业开发。
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| 关 键 词： | 3-羟基-2-丁酮 磷酸氢二铵 2,3,5,6-四甲基吡嗪 |
Study on Synthesis of 2,3,5,6-Tetramethylpyrazine by An Easy Method |
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| ZHAO Wei;LIU Chunbo;WANG Kunmiao;HAN Jingmei;HE Pei;LIU Zhihua. Study on Synthesis of 2,3,5,6-Tetramethylpyrazine by An Easy Method[J]. Flavour Fragrance Cosmetics, 2013, 0(5): 17-18 |
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| Authors: | ZHAO Wei LIU Chunbo WANG Kunmiao HAN Jingmei HE Pei LIU Zhihua |
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| Affiliation: | ZHAO Wei LIU Chunbo WANG Kunmiao HAN Jingmei HE Pei LIU Zkikua (Key Lab of Tobacco Chemistry of Yunnan Province, Yunnan Academy of Tobacco Science, Kunming 650106, Yunnan, China) |
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| Abstract: | With the acceleration role of diammonium hydrogen phosphate, an easy method for synthesis of 2,3,5,6-tetrameth ylpyrazine from 3 hydroxy 2 butanone was studied, and different ammonium salts were investigated and compared. The results showed that when 3 hydroxy-2-butanone and diammonium hydrogen phosphate were mixed and rested at room temperature for 24 h, then after washing and filtering, 2,3,5,6-tetramethylpyrazine could be obtained with the total yield over 50%. |
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| Keywords: | 3-hydroxy 2 butanone diammonium hydrogen phosphate 2 3 5 6 tetramethylpyrazine |
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