Role of Exosomal miRNA in Bladder Cancer: A Promising Liquid Biopsy Biomarker |
| |
| Authors: | Xuan-Mei Piao Eun-Jong Cha Seok Joong Yun Wun-Jae Kim |
| |
| Affiliation: | 1.Department of Urology, College of Medicine, Chungbuk National University, Cheongju 28644, Korea; (X.-M.P.); (S.J.Y.);2.Department of Biomedical Engineering, College of Medicine, Chungbuk National University, Cheongju 28644, Korea;3.Institute of Urotech, Cheongju 28120, Korea;4.Department of Urology, Chungbuk National University Hospital, Cheongju 28644, Korea |
| |
| Abstract: | Bladder cancer (BCa) is the most prevalent neoplasia of the urinary tract. Unfortunately, limited improvements in effective BCa management have meant that it remains a challenging disease. Cystoscopy has been the gold standard for BCa diagnosis and surveillance for over two centuries but is an invasive and expensive approach. Recently, liquid biopsy has been identified as a promising field of cancer research, due to its noninvasiveness and ease of sampling. Liquid biopsy samples could provide comprehensive information regarding the genetic landscape of cancer and could track genomic evolution of the disease over time. Exosomes, which contain RNAs, DNAs, and proteins, are a potential source of tumor biomarkers in liquid biopsy samples. In particular, exosomal miRNAs (exomiRs) hold great promise as biomarkers for tumor development and progression. In this review, we provide an overview of liquid biopsy biomarkers, with a particular focus on the use of exomiRs as biomarkers of cancer, and summarize their clinical implications for BCa. Finally, we discuss the future perspectives of these biomarkers in cancer research. |
| |
| Keywords: | bladder cancer liquid biopsy exosome exosomal miRNAs |
|
|
