Plasminogen Receptors and Fibrinolysis |
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| Authors: | Lindsey A Miles Lina Ny Malgorzata Wilczynska Yue Shen Tor Ny Robert J Parmer |
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| Affiliation: | 1.Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA;2.Department of Medical Biochemistry and Biophysics, Umeå University, 90187 Umeå, Sweden; (L.N.); (M.W.); (Y.S.); (T.N.);3.Department of Medicine, University of California San Diego, La Jolla, CA 92093, USA and Veterans Administration San Diego Healthcare System, San Diego, CA 92161, USA; |
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| Abstract: | The ability of cells to promote plasminogen activation on their surfaces is now well recognized, and several distinct cell surface proteins have been demonstrated to function as plasminogen receptors. Here, we review studies demonstrating that plasminogen bound to cells, in addition to plasminogen directly bound to fibrin, plays a major role in regulating fibrin surveillance. We focus on the ability of specific plasminogen receptors on eukaryotic cells to promote fibrinolysis in the in vivo setting by reviewing data obtained predominantly in murine models. Roles for distinct plasminogen receptors in fibrin surveillance in intravascular fibrinolysis, immune cell recruitment in the inflammatory response, wound healing, and lactational development are discussed. |
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| Keywords: | plasminogen fibrinolysis plasminogen receptors |
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