| 1-氨基-2-羟基-6-硝基-茚的合成研究 |
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| 引用本文： | 王榆元,冀东,王晓晴,王志峥,贺楚华.1-氨基-2-羟基-6-硝基-茚的合成研究[J].衡阳工学院学报,2010(2):81-83,93. |
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| 作者姓名： | 王榆元 冀东 王晓晴 王志峥 贺楚华 |
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| 作者单位： | [1]南华大学化学化工学院,湖南衡阳421001 [2]中核第四研究设计工程有限公司,河北石家庄050021 [3]南京农业大学食品科技学院,江苏南京210095 [4]祁阳县中医院,湖南祁阳421600 |
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| 基金项目： | 湖南省教育厅基金资助项目（08C762） |
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| 摘 要： | 1-氨基-2-羟基-6-硝基-茚可作药物和农药的中间体．以1-茚酮为原料，经过硝化反应、还原反应、脱水反应、环氧化反应、氨解反应得到1-氨基-2-羟基-6-硝基-茚，反应总收率为20．4％．通过偶极计算，我们确定了硝化产物主产物6-硝基-1-茚酮和副产物-4-硝基-1-茚酮，并通过柱层析对其分离；在环氧化反应中，使用m—CPBA作为环氧化试剂收率远高于其他过氧酸；目标产物后处理方法为，用重结晶代替柱层析．各中间体和目标化合物结构通过核磁共振、红外光谱以确定．
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| 关 键 词： | 1-氨基-2-羟基-6-硝基-茚 1-茚酮 合成 |
Study on the Synthesis of 1 - Animo - 2 - Hydroxy - 6 - Nitroindane |
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| Authors: | WANG Yu-yuan JI Dong WANG Xiao-qing WANG Zhi-zheng HE Chu-hua |
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| Affiliation: | 1. School of Chemistry and Chemical Engineering, University of South China, Hengyang, Hunan 421001, China ; 2. The Fourth Institute of Nuclear Engineering of CNNC, Shijiazhuang, Hebei 050021 , China ; 3. College of Food Science and Technology, Nanjing Agriculture University, Nanjing, Jiangsu 210095, China ; 4. Chinese Traditional Hospital of Qiyang, Qiyang, Hunan 421600, China) |
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| Abstract: | 1 - Animo - 2 - Hydroxy - 6 - Nitroindane can be used for drug and pesticide intermediates. 1 - Animo - 2 - Hydroxy - 6 - Nitroindane was synthesized by nitration, reduction, dehydration, epoxidation and ammination of Inden - 1 - one with the yield of 20. 4%. The main product of nitration 6 - Nitroinden - 1 - one and byproducts 4 - Nitroinden -1 -one has been determined by dipole, and been separated by chromatography. The yield of epoxidation was improved by m - CPBA instead of using other peroxyacid. The post treatment method of the product was improved by recrystatlizing instead of the column separation. The structure of target molecule and intermediates has been proved by 1HNMR and IR . |
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| Keywords: | 1 - Animo - 2 - Hydroxy - 6 - Nitroindane Inden - 1 - one synthesis |
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