A method for exposing rodents to resuspended particles using whole-body plethysmography |
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| Authors: | Lindsay B Wichers Allen D Ledbetter John K McGee Robert B Kellogg William H Rowan III Julianne P Nolan Daniel L Costa William P Watkinson |
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| Affiliation: | (1) Department of Environmental Sciences and Engineering, School of Public Health, University of North Carolina, Chapel Hill, North Carolina 27599, USA;(2) Environmental Media Assessment Group, National Center for Environmental Assessment, Office of Research and Development, Research Triangle Park, North Carolina, 27711, USA;(3) Pulmonary Toxicology Branch, Experimental Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, US. Environmental Protection Agency, Research Triangle Park, North Carolina, 27711, USA;(4) Alion Science and Technology Corporation, Research Triangle Park, North Carolina, 27711, USA;(5) Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, 27711, USA |
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| Abstract: | Background Epidemiological studies have reported increased risks of cardiopulmonary-related hospitalization and death in association
with exposure to elevated levels of particulate matter (PM) across a wide range of urban areas. In response to these findings,
researchers have conducted animal inhalation exposures aimed at reproducing the observed toxicologic effects. However, it
is technically difficult to quantitate the actual amount of PM delivered to the lung in such studies, and dose is frequently
estimated using default respiration parameters. Consequently, the interpretation of PM-induced effects in rodents exposed
via whole-body inhalation is often compromised by the inability to determine deposited dose. To address this problem, we have
developed an exposure system that merges the generation of dry, aerosolized particles with whole-body plethysmography (WBP),
thus permitting inhalation exposures in the unrestrained rat while simultaneously obtaining data on pulmonary function. |
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