| Abstract: | The circadian rhythm parameters (mesores, amplitudes, acrophases) and circadian time course of carbohydrates, and lipids (glucose, glycogen, pyruvate, lactate, total lipids, total phospholipids, total and free cholesterol, triglycerides, and free fatty acids) were studied in normal male subjects aged 20-26 over 24 h in health and over three 24 h cycles after a single alcohol intake between 5 and 6 p. m in a dose inducing an average degree of poisoning. Alcohol disturbed the normal circadian organization of carbohydrate and lipid metabolism. Desynchronization of the rhythm structure in carbohydrate metabolism is observed for a longer period than in lipid metabolism. Metabolic changes persist even when alcohol is eliminated, and become directed contrariwise with respect to some parameters (lactate, total lipids, triglycerides, free fatty acids), that is related to disturbed 24 h periodical pattern and coordination of metabolite processes. Recovery of the initial parameters of lipid and carbohydrate metabolism is observed in 3 days after alcohol intake. |
