| 2-氯-4,5-二氟苯乙酮的合成及工艺研究 |
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| 引用本文： | 张翠娥,刘鸿,李志斌,郑朝民.2-氯-4,5-二氟苯乙酮的合成及工艺研究[J].精细化工中间体,2001,31(1):23-25,28. |
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| 作者姓名： | 张翠娥 刘鸿 李志斌 郑朝民 |
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| 作者单位： | 西安近代化学研究所,陕西,西安,710065 |
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| 摘 要： | 报道了新的医药中间体 2 氯 4 ,5 二氟苯乙酮小试和中试合成研究结果。采用邻二氟苯氯化、酰化合成工艺 ,中试放大试验氯化收率 83% ,酰化收率 86% ,精馏收率 75% ,总收率 53 5% ,产品纯度 98%以上
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| 关 键 词： | 3 4-二氟氯苯 2-氯-4 5-二氟苯乙酮 制备 |
| 文章编号： | 1009-9212(2001)01-0023-03 |
Studies on Synthesis and Technology for 2-chrolo-4,5-difluoroacetophenone |
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| ZHANG Cui e,LIU Hong,LI Zhi bin,ZHENG Chao min.Studies on Synthesis and Technology for 2-chrolo-4,5-difluoroacetophenone[J].Fine Chemical Intermediates,2001,31(1):23-25,28. |
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| Authors: | ZHANG Cui e LIU Hong LI Zhi bin ZHENG Chao min |
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| Abstract: | The synthesis of 2 chloro 4,5 difluoroacetophenone is reported. The technology of chloridization and acylation of ortho difluorobenzene is used. The chloridization yield and acylation yield is 83% and 86% respectively. The fine distillation yield is 75%, and the overall yield is 53.5%. The purity of product is over 98%. |
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| Keywords: | 3 4difluorochlorobenzene 2 chloro 4 5 difluoroacetophenone preparation |
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