儿科人血白蛋白药物利用评价标准的建立与应用

目的：为儿科合理应用人血白蛋白提供参考。方法：以人血白蛋白说明书为基础，参考儿科使用人血白蛋白的相关指南和文献资料，拟订药物利用评价标准初稿并列成专家咨询调查表，通过两轮的专家讨论形成定稿。应用该标准回顾性地对我院儿科2019年6月至2020年1月使用人血白蛋白的住院患儿病历进行评价。结果：本研究建立的标准包括用药指征、用药过程、用药结果3个一级指标及适应证、禁忌证、治疗过程监测、药物应用情况、疗效、不良反应6个二级指标。纳入本次评价的住院患儿病历共269份，其中新生儿占比最高（56.88%）。符合适应证229例，占85.13%；用药前检测血清白蛋白浓度有251例，占93.31%；用药后相关指标达标，症状改善明显的有226例，占84.01%。结论：我院所建立的儿科人血白蛋白药物利用评价标准具有较强的实用性，有利于发现临床用药中存在的问题或不足，促进临床合理用药。

Establishment and application of DUE criteria for human albumin in pediatric patients

AIM: To provide reference for rational application of human albumin in pediatrics. METHODS: On the basis of the human albumin instructions, refer to the relevant guidelines and literature on the use of human albumin in pediatrics, draft the first draft of the Drug Use Evaluation standard and list it into an expert consultation questionnaire, which is finalized through two rounds of expert discussions. This standard was used to retrospectively evaluate the medical records of hospitalized children who used human albumin in the Pediatric Department of our hospital from June 2019 to January 2020. RESULTS: The standards established in this study included three primary indicators of medication indications, medication process, medication results and 6 secondary indicators of indications, contraindications, treatment process monitoring, drug application, efficacy, and adverse reactions. A total of 269 medical records of hospitalized children were included in this evaluation, of which newborns accounted for the highest proportion (56.88%). 229 cases met the indications, accounting for 85.13%; 251 cases were tested for serum albumin concentration before medication, accounting for 93.31%; after medication, the relevant indicators reached the standard, and the symptoms improved significantly in 226 cases, accounting for 84.01%. CONCLUSION: The Drug Use Evaluation criteria for pediatric human albumin established by our hospital has strong practicability, which is conducive to discovering problems or deficiencies in clinical medication and promoting rational clinical use of medication.