Effect of essential fatty acid deficiency on myelin proteins |
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Authors: | Sheldon L. Miller David M. Klurfeld Bernadette Loftus David Kritchevsky |
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Affiliation: | (1) The Wistar Institute of Anatomy and Biology, 36th Street and Spruce, 19104 Philadelphia, PA |
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Abstract: | The effect of essential fatty acid (EFA) deficiency on rat-brain myelin proteins was studied. Rats were maintained on a lipid-free diet and compared with control rats fed the same diet supplemented with 3% corn oil. At 17 days of age, each pup was injected with [3H]leucine and rats from each group were killed over a period of 163 days. Although a large decrease occurred in the total amount of myelin protein per brain, the proportions of constituent myelin proteins remained relatively unchanged. Metabolic studies showed a decrease in the net turnover of myelin proteins analogous to that previously demonstrated for myelin phospholipid (PL). |
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