Degradation behavior of hydrophilized PLGA scaffolds prepared by melt-molding particulate-leaching method: Comparison with control hydrophobic one |
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Authors: | Se Heang Oh Soung Gon Kang Jin Ho Lee |
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Affiliation: | (1) Department of Polymer Science and Engineering, Hannam University, 133 Ojeong Dong, Daedeog Gu, Daejeon, 306-791, Korea |
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Abstract: | Porous PLGA/PVA scaffolds as hydrophilized PLGA scaffolds for tissue engineering applications were fabricated by a novel melt-molding
particulate leaching method (non-solvent method). The prepared scaffolds exhibited highly porous and open-cellular pore structures
with almost same surface and interior porosities (pore size, 200–300 μ m; porosity, about 90%). The in vitro degradation behavior of the PLGA and PLGA/PVA scaffolds was compared at 37∘C in PBS (pH 7.4) with and without the solution change everyday to see the effect of solution pH as well as scaffold hydrophilicity
on the degradation behavior. The changes in dimension, molecular weight, mechanical properties (maximum load and modulus),
and morphology of the scaffolds were examined with degradation time. The degradation behavior of the PLGA and PLGA/PVA scaffolds
was further investigated in vivousing a rat model (subcutaneously implantation). It was observed that both PLGA and PLGA/PVA scaffolds in decreasing pH condition
(PBS no change) showed faster degradation than those in constant pH condition (PBS change everyday), owing to the enhanced
intramolecular depolymerization by the increment of chain hydrophilicity caused by carboxylate groups as well as the autocatalysis
of carboxylic acids accumulated in the solution by the cleavage of PLGA backbone ester bonds. The scaffolds in vivo condition also showed faster degradation than those
in vitro, probably due to the aid of foreign body giant cells or enzymes. The PLGA/PVA scaffold showed slightly faster degradation
than the PLGA scaffold for both in vitro and in vivo conditions.
Author to whom all correspondence should be addressed. |
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