PKB/Akt: connecting phosphoinositide 3-kinase to cell survival and beyond |
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| Authors: | BM Marte J Downward |
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| Affiliation: | Imperial Cancer Research Fund, London, UK. |
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| Abstract: | PKB/Akt is a serine/threonine kinase that contains a pleckstrin-homology (PH) domain and is activated in response to growth-factor treatment of cells by a mechanism involving phosphoinositide 3-OH kinase. PKB/Akt provides a survival signal that protects cells from apoptosis induced by various stresses, perhaps explaining its discovery as a retroviral oncogene and its amplification in many human tumours. |
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