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| 手性拆分剂2-苯基-1-对-甲苯基乙胺的合成研究 | |
| 引用本文： | 薛群翔,李英杰,樊群峰,蔡元.手性拆分剂2-苯基-1-对-甲苯基乙胺的合成研究[J].应用化工,2009,38(7):1007-1009. |
| 作者姓名： | 薛群翔 李英杰 樊群峰 蔡元 |
| 作者单位： | 1. 陕西省石油化工研究设计院,陕西,西安,710054 2. 禹城市第一中学,山东,禹城,251200 3. 陕西城化股份有限公司,陕西,城固,723200 |
| 摘 要： | 研究了拆分剂2-苯基-1-对-甲苯基乙胺的合成路线,先通过傅克酰基化反应,温度控制在10℃左右,反应时间为5~6 h,合成2-苯基-1-对-甲苯基乙酮;然后通过胺化反应,温度控制在80~85℃,反应时间10 h,得到2-苯基-1-对-甲苯基乙酮肟;最后通过高压釜催化剂进行加氢,压力控制在2 MPa,温度控制在60℃,反应约4 h,生成2-苯基-1-对-甲苯基乙胺。 |
| 关 键 词： | 拆分 酰基化 胺化 催化加氢 |
Study on synthesis of chiral split agent 2-phenyl-1-p-tolylethylamine |
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| XUE Qun-xiang,LI Ying-jie,FAN Qun-feng,CAI Yuan.Study on synthesis of chiral split agent 2-phenyl-1-p-tolylethylamine[J].Applied chemical industry,2009,38(7):1007-1009. | |
| Authors: | XUE Qun-xiang LI Ying-jie FAN Qun-feng CAI Yuan |
| Abstract: | The synthetic route of split agent of 2-phenyl-1-p-tolyl triethylamine was investigated.2-Phenyl-1-p-tolylethylethanone was synthesized by acylation reaction,reaction temperature was about 10 ℃,reaction time was 5～6 h.2-Phenyl-1-p-tolylethanone oxime was synthesized by amination reaction,reaction temperature was 80～85 ℃,reaction time was 10 h.When pressure was 2 MPa,reaction temperature was 60 ℃,reaction time was 4 h,2-phenyl-1-p-tolylethanamine was synthesized by catalytic hydrogenation reaction. |
| Keywords: | split acylation amination catalytic hydrogenation |
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