| 丙双吗啉对(AT2153)乏氧的人肺腺癌细胞系(SPC-A-1)的辐射增敏活性研究 |
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| 引用本文： | 马承武,薛永泉,罗祖玉.丙双吗啉对(AT2153)乏氧的人肺腺癌细胞系(SPC-A-1)的辐射增敏活性研究[J].辐射研究与辐射工艺学报,1989(3). |
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| 作者姓名： | 马承武 薛永泉 罗祖玉 |
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| 作者单位： | 复旦大学 上海
(马承武，薛永泉)，复旦大学 上海(罗祖玉) |
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| 摘 要： | 一种属于哌嗪二酮类衍生物的抗癌新药—丙双吗啉(AT_(2153),MST_(-02))是由任云峰等合成的,它对多种肿瘤有显著作用,对小鼠肉瘤S_(37)也有辐射增强作用。本工作利用细胞集落形成技术,研究丙双吗啉对乏氧条件下离体培养的人肺腺癌细胞系(SPC-A-1)的辐射增敏效应,在药物浓度为0.1mmol dm~(-3)时,增敏比(SER)为1.22,C_(1.6)值为0.29m mol·dm~(-3)。丙双吗啉是一种具有潜在能力的辐射增敏剂。
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| 关 键 词： | 派嗪二酮类衍生物(AT2153 MST_(-02)) 增敏比(SER) SPC-A-1细胞系 集落形成技术 |
RADIOSENSITIZATION OF AT2153 ON HUMAN LUNG ADENOCARCINOMA CELL LINE SPC-A-1 |
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| Ma Chengwu,Xue Yongquan,Luo Zuyu Dept. of Physiology and Biophysics,Fudan University,Shanghai.RADIOSENSITIZATION OF AT2153 ON HUMAN LUNG ADENOCARCINOMA CELL LINE SPC-A-1[J].Journal of Radiation Research and Radiation Processing,1989(3). |
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| Authors: | Ma Chengwu Xue Yongquan Luo Zuyu Dept of Physiology and Biophysics Fudan University Shanghai |
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| Abstract: | A new antitumour agent of diketopiperazine derivative, dl-1,2-bis(4-morpholinemethyl-3, 5-dioxopiperazin-1-yl)propane (AT 2153, MST-02) was sy-nthesized by Y. F. Ren et al. It exhibited significant activities against several kin-ds of cancer and radiopotentiating effect on Sarcoma S37 in mice. The radiosensitizing effect of AT 2153 was studied with hypoxic Human LungAdeno-carcinoma cell line SPC-A-1 in vitro. Using colony-forming technique. itsSER is 1.22 at the concentration of 0. 10 m mol dm~(-3), and the C 1.6 is 0.29 m moldm~(-3). It might be a potent radiosensitizer. |
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| Keywords: | Diketopiperazine derivative (AT 2153 MST-02) Sensitization enhancement ratio(SER) SPC-A-1 cell line Colony-forming technique |
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