Anticancer,antioxidant, and antimicrobial activities of anemone (Anemone cathayensis) |
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Authors: | Wang Jun-li Liu Kun Gong Wei-zhen Wang Qian Xu Dong-ting Liu Ming-fei Bi Kai-li Song Yun-fei |
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Affiliation: | 1.College of Life and Environmental Sciences, Minzu University of China, Beijing, 100081, China ;2.College of Biology Science and Engineering, Hebei University of Economics and Business, Shijiazhuang, 050061, China ; |
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Abstract: | This study was performed to evaluate the anticancer, antioxidant, and antimicrobial activities of fractions and isolated compounds
from anemone (Anemone cathayensis). Fourteen compounds were isolated from extracts. Anticancer activities of fractions and compounds were determined by MTT
assay, and all tested fractions showed inhibition activity on human breast cancer cells (MDA-MB-231). The fraction 6 displayed
the strongest anticancer activity, and inhibition percent was 50.32%. The antioxidant effect of fractions was evaluated by
using DPPH scavenging assays. Fraction 5 had a higher DPPH radical scavenging activity with low IC50 value of 30.578 μg/mL. The antimicrobial activity of the fractions was evaluated against 3 microorganisms using the agar
well diffusion method. The fractions also showed moderate antimicrobial activity. These results suggest that anemone could
hold a good potential source for human health. |
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