Critical role of plectin in anti-migration potential of curcumin |
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Authors: | Young Ran Ha Yong Wook Choi Sang Joon Lee |
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Affiliation: | 1. Center for Biofluid and Biomimic Research, Pohang University of Science and Technology, Pohang, Gyeongbuk, 790-784, Korea 2. Department of Life Sciences, Pohang University of Science and Technology, Pohang, Gyeongbuk, 790-784, Korea
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Abstract: | Plectin, a linker protein that organizes the cytoskeleton, is critical for cell migration and wound healing. It is specifically
expressed in epithelial cells, muscles, and other tissues. Numerous studies have shown that curcumin (diferuloylmethane) has
anti-cancer potential. Curcumin can inhibit cancer cell migration and invasion through various signaling pathways. In this
study, the down-regulation of plectin expression by siRNA was observed to induce the migration and invasion of human breast
and lung cancer cell lines. Interestingly, the down-regulation of plectin expression by siRNA reversed the curcumin-induced
anti-migration and anti-invasion effects in both cancer cell lines while α-tocopherol and genistein inhibited knockdown of
plectin induced cancer cell migration. Curcumin did not affect the expression of plectin; however, α-tocopherol and genistein
inhibited migration in plectin down-regulated cancer cells. These findings support the novel role of plectin and its effect
on the anti-migration and anti-invasion potential of curcumin. |
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