Effects of mixing,seeding, material of baffles and final temperature on solution crystallization of l-glutamic acid in an oscillatory baffled crystallizer |
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| Authors: | Xiongwei Ni Anting Liao |
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| Affiliation: | 1. Department of Materials Science and Engineering (WW), Institute of Glass and Ceramics (WW3), Friedrich-Alexander-University Erlangen-Nuremberg (FAU), Martensstrasse 5, D-91058 Erlangen, Germany;2. Institute of Chemical Technology, Vietnam Academy of Science and Technology (VAST), No 1, Mac Dinh Chi Street, District 1, Ho Chi Minh City, Viet Nam;3. Interdisciplinary Centre for Functional Particle Systems (FPS), Friedrich-Alexander-University Erlangen-Nuremberg, 91058 Erlangen, Germany;4. Vietnamese-German University (VGU), Le Lai Street, Hoa Phu Ward, Thu Dau Mot City, Binh Duong Province, Viet Nam;1. The University of Western Ontario, Department of Chemical and Biochemical Engineering, London, Ontario N6A 5B9, Canada;2. Tianjin University, School of Chemical Engineering and Technology, State Key Laboratory of Chemical Engineering, Tianjin 300072, PR China;1. Department of Chemical Engineering, University of California, Santa Barbara, California 93106, USA;2. Eli Lilly & Company, Indianapolis, Indiana 46285, USA |
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| Abstract: | In this paper, we report the effects of mixing intensity, seeding, composition of baffle material and final temperature on meta-stable zone width (MSZW) and crystal polymorph in solution crystallization of an industrially important compound, l-glutamic acid, in an oscillatory baffled crystallizer (OBC). The results show that the MSZW decreases with increasing of mixing; meta-stable α crystals are transformed into stable β crystals with enhanced mixing intensity. Seeding meta-stable α crystals in operational conditions that promote β crystals leads to the formation of α crystals allowing co-existence of both forms; while seeding stable β crystals in conditions that favour α form allow β crystals prevailing in all conditions. Smoother surface of baffle material in OBC exhibits larger MSZW and favours meta-stable crystals, while rougher surface has smaller MSZW with stable crystals dominating. The meta-stable crystals gradually change into the stable form when final cooling temperature is closer to its nucleation temperature. The outcomes from this work indicate that by controlling process parameters desirable crystal polymorph can be obtained in the OBC. |
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