| 聚乙二醇SAS微粒化的研究 |
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| 引用本文： | 蒋春跃,谢芳宁,潘勤敏,吴家龙. 聚乙二醇SAS微粒化的研究[J]. 高校化学工程学报, 2001, 15(6): 596-599 |
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| 作者姓名： | 蒋春跃 谢芳宁 潘勤敏 吴家龙 |
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| 作者单位： | 浙江大学高分子工程研究所,浙江,杭州,310027 |
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| 基金项目： | 浙江大学曹光彪高科技发展基金资助项目。 |
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| 摘 要： | 经SAS微粒化实验研究,确定了聚乙二醇SAS沉析操作的优化条件:温度为25℃、压力为8MPa,反萃取剂CO2的密度为0.778gL-1,聚乙二醇/丙酮溶液的浓度为5~15 gL-1,溶液流量为1~5mLmin-1,过程为连续操作。实验所得聚乙二醇微粒的平均尺寸小于0.1mm,而其尺寸分布为0.033~0.38mm。
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| 关 键 词： | 超临界反萃取剂 沉析 聚乙二醇 微粒化 药物缓释剂 |
| 文章编号： | 1003-9015(2001)06-0596-04 |
| 修稿时间： | 2000-03-29 |
Study on Supercritical Antisolvent Precipitation of Polyethylene Glycol |
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| JIANG Chun-yue,XIE Fang-ning,PAN Qin-min,WU Jia-long. Study on Supercritical Antisolvent Precipitation of Polyethylene Glycol[J]. Journal of Chemical Engineering of Chinese Universities, 2001, 15(6): 596-599 |
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| Authors: | JIANG Chun-yue XIE Fang-ning PAN Qin-min WU Jia-long |
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| Abstract: | On the basis of study on the experiment of supercritical antisolvent precipitation of polyethylene glycol, the optimal precipitation conditions were obtained: the temperature 298K, pressure 8MPa, density of antisolvent CO2 0.778 gL-1, concentration of the glycol/acetone solution 5~15 gL-1, and throughput of the solution 1~5mLmin-1. The process is operated continuously. The average size of the particles obtained in this experiment is less than 0.1 mm, and the particle size distribution is in the range of 0.033 to 0.38 mm. |
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| Keywords: | supercritical antisolvent particle precipitation polyethylene glycol |
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