Natural products from Bacillus subtilis with antimicrobial properties☆ |
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作者姓名: | Tao Wang Yafei Liang Mianbin Wu Zhengjie Chen Jianping Lin Lirong Yang |
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作者单位: | 1.Key Laboratory of Biomass Chemical Engineering of Ministry of Education, Hangzhou 310027, China;2.Department of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310027, China;3.JinhuaPeople's Hospital, Jinhua 321000, China;4.Zhejiang Key Laboratory of Antifungal Drugs, Taizhou 318000, China |
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基金项目: | and the Science and Technology Project of Zhejiang Province,the Major State Basic Research Development Program of China,the National High-Tech Research and Development Program of China |
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摘 要: | Bacil us subtilis produces many chemical y-diverse secondary metabolites of interest to chemists and biologists. Based on this, this review gives a detalled overview of the natural components produced by B. subtilis including cyclic lipopeptides, polypeptides, proteins (enzymes), and non-peptide products. Their structures, bioactive ac-tivities and the relevant variants as novel lead structures for drug discovery are also described. The challenging effects of fermentation metabolites, isolation and purification, as wel as the overproduction of bioactive com-pounds from B. subtilis by metabolic engineering, were also highlighted. Systematical y exploring biosynthetic routes and the functions of secondary metabolites from B. subtilis may not only be beneficial in improving yields of the products, but also in helping them to be used in food industry and public medical service on a large-scale.
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关 键 词: | Bacillus subtilis Antimicrobial Bioseparation Drug design |
收稿时间: | 2013-10-10 |
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