Oral delivery of low molecular weight heparin in rat cardiac allografts |
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Authors: | K Teranishi RS Poston BA Reitz RC Robbins |
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Affiliation: | Ruhrlandklinik, Dept of Pneumology, University of Essen, Germany. |
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Abstract: | A 44 yr-old female with severe pulmonary emphysema and reduced alpha-1-protease inhibitor (alpha1-PI) serum levels developed an acute anaphylactic reaction following the third intravenous infusion of human alpha1-PI which was administered to prevent the progression of pulmonary emphysema. Specific immunoglobulin E-antibodies against human alpha1-PI could be demonstrated in the patient's serum using an enzyme allergosorbent test. Because of the risk of further severe anaphylactic reaction, the replacement therapy with alpha1-PI was discontinued. Physicians should be aware of this rare complication. |
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