| 白细胞介素-6及肿瘤坏死因子对受照小鼠造血恢复的影响 |
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| 引用本文： | 周华云,周剑影,王国权,段莹莹,戴宏,郭晓葵,李元. 白细胞介素-6及肿瘤坏死因子对受照小鼠造血恢复的影响[J]. 辐射防护, 2001, 21(4): 232-237 |
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| 作者姓名： | 周华云 周剑影 王国权 段莹莹 戴宏 郭晓葵 李元 |
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| 作者单位： | 苏州大学附属二院肿瘤职业病科,中国核工业辐射损伤医学应急中心, |
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| 摘 要： | 采用PHILIPS－SL18型电子直线加速器产生的6MV高能X射线照射Balb/c小鼠（剂量为6．5Gy),照后不同时间皮下注射不同剂量的白细胞介互－6（IL－6）和／或肿瘤坏死因子（TNF）,观察外周血白细胞,血小板,骨髓有核细胞计数和脾集落形成单位（CFU－S）的变化,以探讨IL－6对放射损伤后造血恢复的影响,结果表明,照射后应用IL－6组较对照组外周血白细胞,血小板和骨髓有核细胞计数恢复快,且呈量依赖关系,CFU－S则在TNF与IL－6协同作用时数量多,体积大,提示IL－6和TNF有利于放射损伤后的造血恢复。
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| 关 键 词： | 白细胞介素－6 造血 小鼠 肿瘤坏死因子 辐射损伤 急性造血功能衰竭 治疗 X射线 放射损伤 |
EFFECTS OF IL-6 AND TNF ON RECOVERY OF HEMATOPOIESIS IN IRRADIATED MICE |
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| Zhou Huayun Zhou Jianying Wang Guoquan Duan Yingying Dai Hong Guo Xiaokui Li Yuan. EFFECTS OF IL-6 AND TNF ON RECOVERY OF HEMATOPOIESIS IN IRRADIATED MICE[J]. Radiation Protection, 2001, 21(4): 232-237 |
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| Authors: | Zhou Huayun Zhou Jianying Wang Guoquan Duan Yingying Dai Hong Guo Xiaokui Li Yuan |
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| Abstract: | After whole body irradiation to the Balb/c mice of 6.5 Gy X-rays of 6 MV energy produced by PHILIPS-SL18 type linear accelerator , the changes of WBCs and PLTs in peripheral blood, nucleated cells in bone marr ow and colony-forming units of spleen (CFU-S) after subcutaneous injection of different doses of interleukin-6 (IL-6) and/or tumour necrosis factor (TNF) we re observed. The effects of IL-6 on hematopoiesis after radiation injuries were studied. The results showed that the recovery of WBCs and PLTs in peripheral bl ood and the nucleated cells in bone marrow was more rapid in the IL-6 groups th an that in the control group and the effects of IL-6 were correlated with its d oses. The CFU-S became more and bigger when IL-6 and TNF were associated with each other than administered separately. It suggests that IL-6 is beneficial to recovery of hematopoiesis after radiation injuries. TNF may have synergetic rol e with IL-6 on hematopoiesis after radiation injuries. ( |
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| Keywords: | Interleukin-6 Radiation Hematopoiesis) |
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