基于磁悬浮式基因生物成像扫描仪电磁结构设计

针对常规基因生物芯片成像系统由于基因芯片位姿调整频繁而引起的调整机构机械磨损的关键问题，设计一种基于磁悬浮的基因生物芯片成像扫描仪。根据基因生物芯片成像扫描仪的工作原理及磁悬浮技术的结构特点，建立由电磁参数与成像分辨率组成的系统微分阵列，通过理论优化确定电磁结构参数，采用有限元分析法对系统进行电磁热结构耦合分析，优化分析结果并搭建实验测试装置。利用本装置对基因生物芯片成像扫描仪进行参数标定，验证扫描仪磁悬浮系统结构设计结果，并与进口PCR仪进行实验测试数据比对。结果表明，本文设计的磁悬浮式基因生物成像扫描仪电磁结构匝数为340 N时产生的有效电磁面积为180 mm~2,此时磁悬浮系统精度误差小于0.15 mm,与仿真数据基本吻合，与美国Bio-Rad数字PCR系统做T790M突变检测的数据对比实验所测得结果CV<5%。本文设计的基于磁悬浮的基因生物芯片成像扫描仪精度可以满足基因生物芯片成像检测的要求，为提升调整装置使用寿命方面提供核心技术保障，在提升临床肿瘤筛查、基因诊断技术中发挥重要的作用。

Magnetic structure design based on magnetic levitation type gene biological imaging scanner

The mechanical wear of adjustment mechanism in the conventional gene biochip imaging system caused by frequent adjustment of gene chip pose is a key problem. To address this issue, a gene biochip imaging scanner based on magnetic levitation is designed. According to genetic biochip imaging scanner work principle and structure characteristics of magnetic suspension technology, a system is established, which consists of electromagnetic parameters and the imaging resolution differential array. Through the theory of optimization, the structure parameters are determined. The finite element analysis is used to analyze the system structure of electromagnetic heat coupling, optimize analysis results and set up the experimental test equipment. The device is used to calibrate the parameters of the gene biochip imaging scanner, verify the magnetic levitation system structure design results of the scanner, and compare the experimental test data with the imported PCR instrument. Results show that when the number of turns of electromagnetic structure of the designed magnetic levitation genetic biological imaging scanner is 340 N, the effective electromagnetic area is 180 mm 2 , and the accuracy error of magnetic levitation system is less than 0. 15 mm. They are basically consistent with the simulation data. Compared with the data of T790M mutation detection by bio-RAD digital PCR system in the United States, CV is less than 5% . The precision of the designed gene-biochip imaging scanner based on magnetic levitation can meet the requirements of gene-biochip imaging detection, provide core technical support for improving the service life of the adjustment device, and play an important role in improving the gene-diagnosis technology of clinical tumor screening.