| 2-羟基吡啶的合成工艺 |
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| 引用本文： | 张丹丹,瞿军,陆文辉,张符,吴宏祥,宋祥波,朱幸丹,钱豪.2-羟基吡啶的合成工艺[J].河北化工,2010,33(6):48-49. |
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| 作者姓名： | 张丹丹 瞿军 陆文辉 张符 吴宏祥 宋祥波 朱幸丹 钱豪 |
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| 作者单位： | 1. 浙江省绍兴文理学院化学化工学院,浙江,绍兴,312000
2. 江苏省扬州普林斯化工有限公司,江苏,扬州,225654 |
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| 摘 要： | 用2-氯吡啶与KOH在乙二醇中反应得到2-羟基吡啶的碱金属盐,再经中和得目标产物2-羟基吡啶。采用溶解度好、沸点合适的乙二醇作溶剂,不仅对原料2-氯吡啶的溶解度较好,还对KOH具有较好的溶解效果,使得反应能均相进行。该工艺操作简单,反应条件温和,副产物少,产品总收率达到90.4%。
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| 关 键 词： | 2-羟基吡啶 2-氯吡啶 乙二醇 |
The Synthetic Technology of 2-Hydroxylpyridine |
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| ZHANG Dan-dan,QU Jun,LU Wen-hui,ZHANG Fu,WU Hong-xiang,SONG Xiang-bo,ZHU Zing-dan,QIAN Hao.The Synthetic Technology of 2-Hydroxylpyridine[J].Hebei Chemical Engineering and Industry,2010,33(6):48-49. |
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| Authors: | ZHANG Dan-dan QU Jun LU Wen-hui ZHANG Fu WU Hong-xiang SONG Xiang-bo ZHU Zing-dan QIAN Hao |
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| Affiliation: | 1.Department of Chemistry Shaoxing University,Shaoxing 312000,China;2.Yangzhou Princechem Co.,Ltd,Yangzhou 225654,China) |
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| Abstract: | Alkali metal salt of 2-hydroxypyridine can be obtained by the reaction of 2-chloropyridine and KOH in ethylene glycol,and 2-hydroxylpyrine was also got by neutralization with HCl.This technology uses ethylene glycol as solvent,that has good solubility and suitable boiling point.By this method,simple operation,mild conditions and less by-product were observed.The overall yield is 90.4%. |
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| Keywords: | 2-hydroxylpyridine 2-chloropyridine ethylene glycol |
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