A pilot study of oral sumatriptan as intermittent prophylaxis of menstruation-related migraine |
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Authors: | LC Newman RB Lipton CL Lay S Solomon |
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Affiliation: | Department of Neurology, The Albert Einstein College of Medicine, Montefiore Headache Unit, Bronx, NY 10467, USA. |
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Abstract: | Headaches associated with menstruation are often resistant to abortive and preventative medications. We performed an open-label study in 20 female migraineurs, employing oral sumatriptan perimenstrually as short-term prophylaxis of menstrual migraine. In 126 sumatriptan-treated cycles, headache was absent in 52.4% and reduced in severity by 50% or greater in 42%. Breakthrough headaches were rare and significantly reduced in severity compared with baseline headaches. |
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