抗粒细胞单克隆抗体与HIG在炎症模型鼠体内生物分布的对比

通过对抗人粒细胞单克隆抗体（McAb）及人丙种球蛋白（HIG）在炎症模型鼠体内生物分布的对比性研究,比较两种炎症显像剂在炎症模型鼠体内生物分布的差异。结果表明McAb和HIG在肝、脾和骨髓均浓聚较高放射性,但McAb组浓聚量明显高于HIG组,差异显著（P＜0．01） ;McAb组肺、胃肠及肌肉的放射性明显低于HIG组;McAb组外周血放射性明显低于HIG组,且消退迅速;两组肾脏均有较高放射性浓聚。注射抗体后6h及9h,两组炎症肢体（靶）与对侧健肢（非靶）的％ID值的比值（T／NT）差异不显著,但24h McAb组T／NT明显高于HIG组,差异显著（P＜0．05）。McAb可使炎症肢体炎症部位明显显影,但早期优越性并不比HIG明显,延迟显像时McAb比HIG优越;McAb对肺、胃肠及肌肉部位的炎症病灶显像较HGI优越。

Comparison of biodistribution of monoclonal antigranulocyte antibody and HIG in inflammatory model mice

Through the comparative study of biodistribution of monoclonal antigranulocyte antibody and HIG in inflammatory model rats, the difference of biodistribution of these two kinds of agents in inflammatory model rats were compared. The results showed that both McAb and HIG had much accumulation in liver, spleen and marrow. The accumulation in McAb group was higher than that in HIG group, the difference between the two groups was statistically significant ( P <0.01); McAb group showed lower radioactivity than HIG group in lung, stomach, intestine and muscle; McAb group has significant lower radioactivity than HIG group in blood and the radioactivity in blood disappeared rapidly in McAb group; the kidney accumulated very much radioactivity in two groups. The difference of the ratio of %ID between inflammatory limb (target) and contralateral healthy limb (no target) (T/NT) was insignificant in two groups at six and nine hours after injection of antibody, but McAb group owned higher T/NT ratio than HIG group at twenty-four hours, the difference has statistical significance ( P <0.05). The McAb was able to image the inflammatory sites in inflammatory limb, but the superiority of McAb was less obvious than HIG at early stage. McAb is more suitable to image the inflammatory sites in lung, stomach, intestine and muscle than HIG.