| 提高麻疹乙脑二联活疫苗热稳定性的研究 |
| |
| 引用本文： | 姚亚夫,张卓光.提高麻疹乙脑二联活疫苗热稳定性的研究[J].粉末涂料与涂装,1998,11(1):25-27. |
| |
| 作者姓名： | 姚亚夫 张卓光 |
| |
| 作者单位： | 卫生部成都生物制品研究所!成都，610063，卫生部成都生物制品研究所!成都，610063，卫生部成都生物制品研究所!成都，610063，卫生部成都生物制品研究所!成都，610063，卫生部成都生物制品研究所!成都，610063，卫生部成都生物制品研究所!成都，610063，卫生部成都生物制品研究所!成都，610 |
| |
| 摘 要： | 首先对3种保护剂冻干的麻疹乙脑二联苗进行滴度比较，结果3种保护剂的二联疫苗中麻疹病毒滴度差异均无显著意义；而对乙脑病毒滴度显示出保护剂Ⅱ和Ⅲ明显优于Ⅰ。选择保护剂Ⅲ制备二联苗和单价苗进行热稳定性试验，其中麻疹病毒在37℃对天及50℃72h的滴度下降均＜1．0Log。乙脑病毒在37℃14天及在50℃24h滴度下降均＜1．0Log。表明保护剂Ⅲ对麻疹沪191株和乙脑14－2株病毒的热保护作用均好。
|
| 关 键 词： | 麻疹乙脑二联活疫苗 保护剂 热稳定性 |
Improvement of Heat Stability of Live Measles-Japanese Encephalitis Vaccine |
| |
| Yao Yafu, Zhang Zhuoguang Wang Hongbin,et al.Improvement of Heat Stability of Live Measles-Japanese Encephalitis Vaccine[J].Chinese Journal of Biologicals,1998,11(1):25-27. |
| |
| Authors: | Yao Yafu Zhang Zhuoguang Wang Hongbin |
| |
| Abstract: | The titers of live measles-Japanese encephalitis (JE) vaccines using 3 kinds ofprotective agents were compared. The resu1t showed no significant difference among themeasles virus titers of them. However, the JE virus titers of the vaccines using protectiveagents Ⅱ and Ⅲ were significantly higher than that using protective agent Ⅰ. Theheat stabilities of monovalent measles, JE and bivalent measles-JE vaccines using protective agent Ⅲwere studied. The titer of measles virus decreased by <1. 0Log after being stored at 37℃ for21 days or 50℃ for 72h, and that of JE virus decreased by <1.0Log after being stored at37℃ for 14 days or 50℃ for 24h. The results showed good protection of agent Ⅲ to Hu191strain of measles virus and SA14-14-2 strain of JE virus. |
| |
| Keywords: | Live measles-JE vaccine Protective agent Heat stability |
| 本文献已被 CNKI 维普 等数据库收录！ |
