| 甲肝减毒活疫苗(L-A-1)免疫持久性观察 |
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| 引用本文： | 刘景晔 郭建军. 甲肝减毒活疫苗(L-A-1)免疫持久性观察[J]. 中国生物制品学杂志, 1998, 11(2): 116-118 |
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| 作者姓名： | 刘景晔 郭建军 |
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| 作者单位： | 卫生部长春生物制品研究所!长春，130062，卫生部长春生物制品研究所!长春，130062，卫生部长春生物制品研究所!长春，130062，卫生部长春生物制品研究所!长春，130062，卫生部长春生物制品研究所!长春，130062，卫生部长春生物制品研究所!长春，130062，卫生部长春生物制品研究所!长春，130 |
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| 摘 要： | 对接种甲肝减毒活疫苗的222名志愿者进行了连续5年的免疫持久性观察，二批疫苗免后6周抗体阳转率分别为97.36％和97.22％，抗体GMT分别为5．134和5．408；免后3年抗体阳性率为88.89％和89.42％，GMT为2．764和2．406；兔后5年抗体阳性率为80．76％和81．69％，GMT为1．746和1．823。疫苗批间抗体阳性率、GMT差异无显著性意义，表明该疫苗具有良好的免疫原性及免疫持久性。
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| 关 键 词： | 甲肝减毒活疫苗 抗体阳转率 免疫持久性 |
Immune Persistence of Live Attenuated Hepatitis A Vaccine (L-A-1) |
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| Liu Jingye,Guo Jianjun,Wang Wei et al. Immune Persistence of Live Attenuated Hepatitis A Vaccine (L-A-1)[J]. Chinese Journal of Bilogicals, 1998, 11(2): 116-118 |
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| Authors: | Liu Jingye Guo Jianjun Wang Wei et al |
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| Abstract: | The immune persistence of live attenuated hepatitis A vaccine(L-A-1)wasobserved for 5 years in 222 volunteers.The result showed that the HA antibody positive ratesof the volumteers immunized with 2 lots of the vaccine were 97.36% and 97.22% respectively 6 weeks after immunization,and the GMTs of them were 5.134 and 5.408 respectively;three years after immunization,the positive rates were 88.89% and 89.42%,and the GMTswere 2.764 and 2.406 respectively;five years after immunization,the positive rates were 80.76% and 81.69%,and the GMTs were 1.746 and 1.823 respectively.No significant difference was found between the antibody positive rates and GMTs induced by the 2 lots.Itshowed good immunogenicity and immune persistence of the vaccine. |
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| Keywords: | Live attenuated hepatits A vaccine Antibody positive rate Immune persistence |
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