Influence of grape variety and their phenolic composition on vasorelaxing activity of young red wines |
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Authors: | Teresa Ortega Elena De La Hera M Emilia Carretero Pilar Gómez-Serranillos M Victoria Naval Angel M Villar Marin Prodanov Visitación Vacas Teresa Arroyo Teresa Hernández Isabel Estrella |
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Affiliation: | 1. Departamento de Farmacología, Facultad de Farmacia, Universidad Complutense de Madrid, 28040, Madrid, Spain 2. Departamento de Agroalimentación, Instituto Madrile?o de Investigación y Desarrollo Rural, Agrario y Alimentario, Ctra, A-2, km 38.2, 28800, Alcalá de Henares, Madrid, Spain 3. Instituto de Fermentaciones Industriales, CSIC. C/ Juan de la Cierva, 3, 28006, Madrid, Spain
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Abstract: | Red wine has been reported to exert beneficial effects in preventing cardiovascular diseases probably due to their polyphenols
constituents. The vasorelaxant capacity and phenolic composition of four monovarietal young red wines Merlot, Tempranillo,
Garnacha and Cabernet-Sauvignon obtained from grapes from 2004 vintage, cultivated under the same climatic and agricultural
conditions, wine-making technology and storage conditions, were determined using vascular reactivity assay in rat aortic and
high-performance liquid chromatography, respectively. Primary cultures of vascular smooth muscle cells from Wistar rats were
also used to evaluate their survival prevention activity as well. Every studied wine present vasorelaxation effect, but the
higher value corresponds to the analyzed Merlot wine, especially rich in phenolic compounds, mainly catechins and oligomeric
proanthocyanidins and anthocyanin glycosides. This study further demonstrated previous investigations about the phenolic composition
of wines relation with their vasorelaxation activity. |
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Keywords: | Young monovarietal wine Merlot Tempranillo Garnacha Cabernet-Sauvignon Phenolic composition Vasorelaxation Vasoprotective |
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