Significant Enhancement of Photothermal and Photoacoustic Efficiencies for Semiconducting Polymer Nanoparticles through Simply Molecular Engineering |
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| Authors: | Tao Dong Kaikai Wen Jun Chen Jin Xie Weili Fan Han Ma Lei Yang Xiaoxi Wu Fujian Xu Aidong Peng Hui Huang |
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| Affiliation: | 1. College of Materials Science and Opto‐Electronic Technology and CAS Key Laboratory of Vacuum Physics and CAS Center for Excellence in Topological Quantum Computation, University of Chinese Academy of Sciences, Beijing, P. R. China;2. School of Chemistry and Chemical Engineering, Jinzhong University, Jinzhong, P. R. China;3. Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing, P. R. China;4. Key Laboratory of Carbon Fiber and Functional Polymers (Ministry of Education), Beijing Laboratory of Biomedical Materials, Beijing Advanced Innovation Center for Soft Matter Sciences and Engineering, Beijing University of Chemical Technology, Beijing, P. R. China;5. Department of Dermatology, The Third Affiliated Hospital, Sun Yat‐sen University, Guangzhou, Guangdong, P. R. China |
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| Abstract: | Semiconducting polymer nanoparticles (SP NPs) are employed as efficient nanoagents for “all‐in‐one” theranostic nanoplatforms with dual photoacoustic imaging (PAI) and photothermal therapy (PTT) functions based on their photothermal conversion effect. However, the mechanisms of tuning the PTT efficiency are still elusive, though several SP NPs with high photothermal efficiency are reported. Herein, two donor–acceptor (D–A) SP NPs PTIGSVS and PIIGSVS with the same donor unit but different acceptor units are designed and synthesized. Through tuning the acceptor unit, PTIGSVS shows more planar backbone structure, stronger D–A strength, redshifted absorption, enhanced extinction efficient, weakened emission properties, and more efficient nonradiative decay in comparison to the polymeric analogue PIIGSVS . Thus, PTIGSVS NPs present much higher photothermal conversion efficiencies (74%) than PIIGSVS NPs (11%), resulting in significantly enhanced in vitro and in vivo PAI and PTT performance. This contribution demonstrates that PTIGSVS NPs are superior PA/PTT agents for effective cancer theranostic and shed light on understanding the relationship between molecular structures and photothermal effect of CPs. |
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| Keywords: | molecular engineering photoacoustic imaging photothermal therapy semiconducting polymer nanoparticles tumors |
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