Light‐Activatable Assembled Nanoparticles to Improve Tumor Penetration and Eradicate Metastasis in Triple Negative Breast Cancer |
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| Authors: | Jianfeng Ji Fei Ma Hongbo Zhang Fengyong Liu Jian He Wanlin Li Tingting Xie Danni Zhong Tingting Zhang Mei Tian Hong Zhang Hélder A Santos Min Zhou |
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| Affiliation: | 1. Department of Nuclear Medicine, The Second Affiliated Hospital, School of Medicine, Zhejiang University School of Medicine, Hangzhou, P. R. China;2. Institute of Translational Medicine, Zhejiang University, Hangzhou, P. R. China;3. Department of Pharmaceutical Sciences Laboratory and Turku Center for Biotechnology, ?bo Akademi University, Turku, Finland;4. Department of Interventional Radiology, Chinese PLA General Hospital, Beijing, China;5. Department of Nuclear Medicine, The First Hospital, Shanxi Medical University, Taiyuan, P. R. China;6. Drug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland;7. Helsinki Institute of Life Science, HiLIFE, University of Helsinki, Helsinki, Finland;8. Key Laboratory of Cancer Prevention and Intervention, National Ministry of Education, Zhejiang University, Hangzhou, P. R. China;9. State Key Laboratory of Modern Optical Instrumentations, Zhejiang University, Hangzhou, P. R. China |
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| Abstract: | Triple‐negative breast cancer (TNBC) is a kind of aggressive malignancy with fast metastatic behavior. Herein, a nanosystem loaded with a near‐infrared (NIR) agent is developed to achieve chemo‐photothermal combination therapy for inhibiting tumor growth and metastasis in TNBC. The NIR agent of ultrasmall sized copper sulfide nanodots with strong NIR light‐absorbing capability is entrapped into the doxorubicin‐contained temperature‐sensitive polymer‐based nanosystem by a self‐assembled method. The temperature sensitive nanoclusters (TSNCs) can significantly enhance the drug penetration depth and significantly kill the cancer cells under the near‐infrared laser irradiation. Importantly, it is plausible that the tumor penetrating nanosystem combined with NIR laser irradiation can prevent lung and liver metastasis via extermination of the cancer stem cells. The in vivo characteristics, evaluated by photoacoustic imaging, pharmacokinetics, and biodistribution, confirm their feasibility for tumor treatment owing to their long blood circulation time and high tumor uptake. Thanks to the high tumor uptake and highly potent antitumor efficacy, the doxorubicin‐induced cardiotoxicity can be avoided when the TSNC is used. Taken together, it is believed that the nanosystem has excellent potential for clinical translation. |
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| Keywords: | metastasis nanoparticles self‐assembly triple‐negative breast cancer tumor penetration |
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