Gold nanoparticle-based biosensors |
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Authors: | Yuanyuang Li Hermann J Schluesener and Shunqing Xu |
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Affiliation: | (1) Department of Chemical and Materials Engineering, School of Engineering and UDRI, University of Dayton, 300 College Park, Dayton, OH 45469-0240, USA; |
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Abstract: | The unique properties of gold nanoparticles have stimulated the increasing interest in the application of GNPs in interfacing
biological recognition events with signal transduction and in designing biosensing devices exhibiting novel functions. The
optical properties of GNPs provide wide range opportunities for construction optical biosensors. The excellent biocompatibility,
conductivity, catalytic properties and high surface-to-volume ratio and high density of GNPs facilitate extensive application
of GNPs in construction of electrochemical and piezoelectric biosensors with enhanced analytical performance with respect
to other biosensor designs. In this article, the recent advances in construction of GNP-based optical, electrochemical and
piezoelectric biosensors are reviewed, and some illustrative examples given, with a focus on the roles GNPs play in the biosensing
process and the mechanism of GNPs for improving the analytical performances. Finally, the review concludes with an outline
of present and future research for the real-world applications. |
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