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| 以L-谷氨酸为原料制备D-谷氨酸的新方法 | |
| 引用本文： | 翟立海,蒋立建,祝阳,王玉婷. 以L-谷氨酸为原料制备D-谷氨酸的新方法[J]. 应用化工, 2006, 35(4): 313-315 |
| 作者姓名： | 翟立海 蒋立建 祝阳 王玉婷 |
| 作者单位： | 1. 东南大学,化学化工系,江苏,南京,210096 2. 东南大学,化学化工系,江苏,南京,210096;荆门职业技术学院,化学与环境工程系,湖北,荆门,448000 3. 东南大学,化学化工系,江苏,南京,210096;徐州医药高等职业学校,药学技术系,江苏,徐州,221116 |
| 摘 要： | 以L-谷氨酸为原料经过酯化、消旋、化学拆分和水解制备D-谷氨酸。使L-2,3-二苯甲酰酒石酸(L-DBTA)与DL-谷氨酸-γ-乙酯在水溶液中于65~70℃反应形成非对映体盐,冷却到0~5℃,D-谷氨酸.L-DBTA盐析出,过滤后再经水解得到D-谷氨酸,收率85%,旋光纯度达到99%以上。 |
| 关 键 词： | L-谷氨酸-γ-乙酯 DL-谷氨酸-γ-乙酯 D-谷氨酸 拆分 水解 |
| 文章编号： | 1671-3206(2006)04-0313-03 |
| 收稿时间： | 2006-01-03 |
| 修稿时间： | 2006-01-03 |
New method for preparation of D-glutamic acid from L-glutamic acid |
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| ZHAI Li-hai,JIANG Li-jian,ZHU Yang,WANG Yu-ting. New method for preparation of D-glutamic acid from L-glutamic acid[J]. Applied chemical industry, 2006, 35(4): 313-315 | |
| Authors: | ZHAI Li-hai JIANG Li-jian ZHU Yang WANG Yu-ting |
| Abstract: | A new method for preparing D-glutamic acid from L-glutamic acid by esterification,racemization,chemical resolution and hydrolyzation was reported.Reaction of L-2,3-dibenzoyl tartaric acid with DL-glutamic acid-γ-ethyl ester in aqueous solution at 65~70℃ formed diastereoisomeric salts.Salt composed of D-glutamic acid-γ-ethyl ester and L-2,3-dibenzoyl tartaric acid was precipitated when the mixture was cooled to 0~5℃.The salt was hydrolyzed giving D-glutamic acid with yield of 85%,and optical purity 99%. |
| Keywords: | L-glutamic acid-γ-ethyl ester DL-glutamic acid-γ-ethyl ester D-glutamic acid resolution hydrolysis |
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