冬瓜提取物抗小鼠胃溃疡活性研究

冬瓜(B.hispida)是中国的一种常见的蔬菜，本文探讨了冬瓜的不同提取物在抑制乙酰水杨酸所致的小鼠实验性胃溃疡上的活性。冬瓜首先经过脱水再用甲醇萃取并将提取物真空浓缩，然后将提取物中可溶于正丁醇和水的部分分离出来冷冻干燥后用于动物实验。口服不同剂量提取物的小鼠，溃疡的发生率明显的降低了。病理切片的结果表明这些提取物可以保护胃粘膜上皮细胞并抑制溃疡发生。由于冬瓜是一种常见的无毒植物，它与现有的抗胃溃疡的药物相比具有明显的优势，因而在功能食品方面的应用前景非常广阔。

Anti-Gastric Ulcerogenic Activity of Different Extracts of Benincasa hispida in Mice

Benincasa hispida (B. hispida) is a widely consumed vegetable in China. Different B. hispida extracts for anti- ulcerogenic activity were studied in aspirin plus restraint in mice experiment. B. hispida was dehydrated for extracted with methanol and evaporated into extract in vacuum. The n-butanol and water-soluble fractions were freeze-dried as crude sample for animal experiment. The oral feeding of different doses of the extract significantly (p<0.01) reduced the ulcer caused by aspirin. The observing pathological section showed that those extracts could protect the gastric mucosa epithelium and take precautions against ulcer. Thus, being a commonly consumed non-toxic plant, it was advantageous over the presently available anti-ulcer agents. Extracts of B. hispida might be used as functional food additives in the future.