In vitro antimycobacterial activity of 5-chloropyrazinamide |
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| Authors: | MH Cynamon RJ Speirs JT Welch |
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| Affiliation: | Veterans Affairs Medical Center, Syracuse, New York 13210, USA. CYNAMON.MICHAEL@SYRACUSE.VA.GOV |
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| Abstract: | 5-Chloropyrazinamide and 5-chloropyrazinoic acid were evaluated for in vitro activity against Mycobacterium tuberculosis, Mycobacterium bovis, and several nontuberculous mycobacteria by a broth dilution method. 5-Chloropyrazinamide was more active than pyrazinamide against all organisms tested. It is likely that this agent has a different mechanism of action than pyrazinamide. |
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