Synthesis of pH-Responsive Multilayer Micelles for Sustained Release of Folic Acid |
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Authors: | Cuiping Zhai Pan Wang Xuejun Liu |
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Affiliation: | Institute of Fine Chemical and Engineering, Henan University, Kaifeng, Henan, PR China |
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Abstract: | Two novel triblock copolymers poly(hydroxypropyl acrylate)-b-poly (methyl methacrylate)-b-poly(N,N-dimethylaminoethyl methacrylate) and poly(hydroxypropyl acrylate)-b-poly(methyl methacrylate)-b-poly(acrylic acid) were successfully synthesized. In acetone media, using the electrostatic interactions between N,N-dimethylaminoethyl methacrylate and acrylic acid units, they could form spherically shaped multilayer micelles with pH-responsive, and have a mean diameter around 110 nm. The critical micelle concentration of it was determined to be 2.42 mg/L. In vitro release experiments, the folic acid-loaded micelles exhibited sustained release behavior and the drug release rate was affected by the pH value of release media. These results indicate that the multilayer micelles may serve as a novel intelligent drug delivery system. |
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Keywords: | Copolymers drug delivery micelles pH-responsive synthesis |
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