Nanotechnology for Neuroscience: Promising Approaches for Diagnostics,Therapeutics and Brain Activity Mapping |
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| Authors: | Anil Kumar Aaron Tan Joanna Wong Jonathan Clayton Spagnoli James Lam Brianna Diane Blevins Natasha G Lewis Thorne Keyoumars Ashkan Jin Xie Hong Liu |
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| Affiliation: | 1. State Key Laboratory of Crystal Materials, Shandong University, Jinan, China;2. Department of Chemistry, Bio‐Imaging Research Center, University of Georgia, Athens, Georgia, United States;3. Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences, Beijing, China;4. UCL Medical School, University College London (UCL), London, United Kingdom;5. Biomaterials and Advanced Drug Delivery Laboratory (BioADD), Stanford University School of Medicine, Stanford University, Palo Alto, California, United States;6. Imperial College School of Medicine, Imperial College London, London, United Kingdom;7. Queens' College, University of Cambridge, Cambridge, United Kingdom;8. Department of Neurosurgery, National Hospital for Neurology and Neurosurgery, London, United Kingdom;9. Department of Neurosurgery, King's College Hospital NHS Foundation Trust, King's College London, London, United Kingdom |
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| Abstract: | Unlocking the secrets of the brain is a task fraught with complexity and challenge – not least due to the intricacy of the circuits involved. With advancements in the scale and precision of scientific technologies, we are increasingly equipped to explore how these components interact to produce a vast range of outputs that constitute function and disease. Here, an insight is offered into key areas in which the marriage of neuroscience and nanotechnology has revolutionized the industry. The evolution of ever more sophisticated nanomaterials culminates in network‐operant functionalized agents. In turn, these materials contribute to novel diagnostic and therapeutic strategies, including drug delivery, neuroprotection, neural regeneration, neuroimaging and neurosurgery. Further, the entrance of nanotechnology into future research arenas including optogenetics, molecular/ion sensing and monitoring, and piezoelectric effects is discussed. Finally, considerations in nanoneurotoxicity, the main barrier to clinical translation, are reviewed, and direction for future perspectives is provided. |
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| Keywords: | brain activity mapping (BAM) nanoneuroscience nanoneurotoxicity neural regeneration neuroimaging optogenetics |
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