Assembly and Characterizations of Bifunctional Fluorescent and Magnetic Microneedles With One Decade Length Tunability |
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Authors: | Jean‐Baptiste Lugagne Gwennhaël Brackx Emek Seyrek Sophie Nowak Yann Sivry Leticia Vitorazi Jean‐François Berret Pascal Hersen Gaëlle Charron |
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Affiliation: | 1. Laboratoire Matière et Systèmes Complexes, UMR 7057, Université Paris Diderot, Sorbonne Paris Cité, CNRS, Paris cedex 13, France;2. X‐Ray Platform, Chemistry Department, Université Paris Diderot, Sorbonne Paris Cité, Paris cedex 13, France;3. Institut de Géophysique du Globe de Paris, UMR 7154, Université Paris Diderot, Sorbonne Paris Cité, CNRS, Paris, France |
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Abstract: | This report presents the fabrication of bifunctional magnetic and fluorescent microneedles (µNDs) made of a ternary mixture of magnetic nanoparticles (NPs), quantum dots (QDs), and polyelectrolyte. The assembly relies on the electrostatic complexation of negatively charged NPs with positively charged polymer strands and is controlled by the charge ratio between the nanoparticle building blocks and the polymer mortar. The resulting 1D objects can be actuated using an external magnetic field and can be imaged using fluorescence microscopy, thanks to the fluorescent and superparamagnetic properties inherited from their NP constituents. Using a combination of core and surface characterizations and a state‐of‐the‐art image analysis algorithm, the dependence of the brightness and length on the ternary composition is thoroughly investigated. In particular, statistics on hundreds of µNDs with a range of compositions show that the µNDs have a log‐lormal length distribution and that their mean length can be robustly tuned in the 5–50 µm range to match the relevant length scales of various applications in micromixing, bioassays or biomechanics. |
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Keywords: | 1D‐microstructures fluorescence imaging magnetic nanoparticles nanoparticle assembly quantum dots |
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