| 4-（2＇-氟-4＇-氰基苯氧基）苯酚的合成新方法 |
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| 引用本文： | 闫潇敏,宁斌科,王列平,张媛媛,朱利民.4-（2＇-氟-4＇-氰基苯氧基）苯酚的合成新方法[J].化学与粘合,2009,31(6):73-75. |
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| 作者姓名： | 闫潇敏 宁斌科 王列平 张媛媛 朱利民 |
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| 作者单位： | 西安近代化学研究所,陕西,西安,710065 |
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| 摘 要： | 4-（2＇-氟-4＇-氰基苯氧基）苯酚是合成苯氧丙酸类高效除草剂的重要中间体。研究了4-（2＇-氟-4＇-氰基苯氧基）苯酚合成的新方法。该方法以3,4-二氟苯腈和对羟基苯甲醚为主要原料,首先合成4-（2＇-氟-4＇-氰基苯氧基）苯甲醚,再经三溴化硼还原得到4-（2＇-氟-4＇-氰基苯氧基）苯酚。通过红外、核磁及质谱等分析手段对其化学结构进行了鉴定,两步反应总收率为64%,产品纯度95.2%,克服了文献报道的合成方法产量小、收率低的缺点。
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| 关 键 词： | 3 4-二氟苯腈 对羟基苯甲醚 4-(2'-氟-4'-氰基苯氧基)苯甲醚 4-(2'-氟-4'-氰基苯氧基)苯酚 合成 |
New Synthesis Technique of 4-(4'-cyano-2'-fluorophenoxy)Phenol |
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| YAN Xiao-min,NING Bin-ke,WANG Lie-ping,ZHANG Yuan-yuan and ZHU Li-min.New Synthesis Technique of 4-(4'-cyano-2'-fluorophenoxy)Phenol[J].Chemistry and Adhesion,2009,31(6):73-75. |
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| Authors: | YAN Xiao-min NING Bin-ke WANG Lie-ping ZHANG Yuan-yuan and ZHU Li-min |
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| Affiliation: | g (Xi＇ an Modern Chemistry Research Institute, Xi＇ an 710065, China) |
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| Abstract: | 4-（4＇-cyano-2＇-fluorophenoxy） phenol is an important intermediate of phenoxypropionate herbicide. The new synthesis technique of 4-（4＇-cyano-2＇-fluorophenoxy） phenol is reviewed. 4-hydroxyanisole and 3, 4-difluorobenzonitrile is used as the major starting materials to obtain 4-（4＇-eyano-2＇-fluorophenoxy） anisole. Then 4-（4＇-cyano-2＇-fluorophenoxy） phenol is obtained by deoxidizing 4-（4＇-cyano-2＇- fluorophenoxy） anisole with BBr3. Its chemical structure is characterized by IR, ^1H-NMR and mass spectrum. The total yield is 64% and the purity is 95.2%. Thereby this method overcomes the disadvantages of small amount of production and low yield. |
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| Keywords: | 3 |
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