Fourier-domain digital holographic optical coherence imaging of living tissue |
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Authors: | Jeong Kwan Turek John J Nolte David D |
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Affiliation: | Department of Physics, Purdue University, West Lafayette, Indiana 47907-2036, USA. jeongk@physics.purdue.edu |
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Abstract: | Digital holographic optical coherence imaging is a full-frame coherence-gated imaging approach that uses a CCD camera to record and reconstruct digital holograms from living tissue. Recording digital holograms at the optical Fourier plane has advantages for diffuse targets compared with Fresnel off-axis digital holography. A digital hologram captured at the Fourier plane requires only a 2D fast Fourier transform for numerical reconstruction. We have applied this technique for the depth-resolved imaging of rat osteogenic tumor multicellular spheroids and acquired cross-section images of the anterior segment and the retinal region of a mouse eye. A penetration depth of 1.4 mm for the tumor spheroids was achieved. |
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